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Chapter 11: 12-19 Gene Expression - Cloning and Cancer

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Biology Homework Chapter 11: Cloning and Cancer


Reading Preparation

Textbook assignment: Chapter 11: The Control of Genetic Expression, sections 12-19.

Study Notes

Web Lecture

Read the following weblecture before chat: Differentiation of Cells

Take notes on any questions you have, and be prepared to discuss the lecture in chat.

Study Activity

Perform the study activity below:

Use the Gene Expression Essentials exercise below (from PhET):

  • Chose the Expression option first.
    • Click on the positive transcription factor and move it into place. (The outline will show up on the regulatory region).
    • Click on the RNA Polymerase complex and move it into place. When the RNA Polymerase complets its run, move it back to the starting point of the gene and make another mRNA copy of the gene.
    • Move a ribosome into the cell area and feed an mRNA sequence into it at the crease. You can make several copies of the same protein with the same mRNA.
    • What happens if you try to position the negative transcription factor on this gene?
    • Click on "Next Gene". Figure out what transcription factors you need so that the RNA polymerase will attach to the start of the transcription region. Use the mRNA you manufacture with a ribosome to make more proteins of this new type.
    • Do this again for the final gene. Use the mRNA Destroyer to clean up the mRNA you made on the final round. See if you can figure out what the negative transcription factor does!
  • Use the mRNA exercise to explore how the concentrations of transcription factors and RNA polymerase affect the rate of mRNA production. What conditions are necessary for mRNA production? What conditions increase production?
  • If you have time, use the Multiple cells exercise to see how the concentrations and affinities of factors and destroyers affect the level of proteins in the cell.

Chapter Quiz

Lab Work

Read through the lab for this week; bring questions to chat on any aspect of the lab, whether you intend not perform it or not. If you decide to perform the lab, be sure to submit your report by the posted due date.